Goleadores – Segunda División 2021
| Club | Jugador | Goles | Jugados |
|---|---|---|---|
 | Diego Vera | 10 | 22 |
| Diego Coelho | 10 | 22 |
 | Matías Britos | 8 | 21 |
 | Pablo González | 8 | 22 |
 | Luis Aguiar | 7 | 19 |
 | Alejo Cruz | 7 | 21 |
| Catriel Sánchez | 6 | 20 |
| Agustín Sant’ Anna | 6 | 22 |
| Mauricio Alonso | 6 | 21 |
 | Maximiliano Callorda | 6 | 19 |
| Luis Acevedo | 5 | 20 |
| Jairo Villalpando | 5 | 20 |
| Michel Sosa | 5 | 21 |
 | Luis Gorocito | 5 | 21 |
 | Leandro Zazpe | 5 | 15 |
 | Pablo Pereira | 4 | 20 |
 | Brian Cordara | 4 | 21 |
 | Brahian Ferreira | 4 | 21 |
| Gonzalo Sena | 4 | 21 |
| Braian Rodríguez | 4 | 17 |
| Fernando Arismendi | 4 | 20 |
| Maicol Cabrera | 4 | 11 |
 | Alvaro Torres | 3 | 16 |
 | Bryan Osores | 3 | 10 |
| Erik De Los Santos | 3 | 21 |
 | Juan Pintado | 3 | 21 |
| Alvaro Navarro | 3 | 14 |
| Matías Tavares | 3 | 17 |
| Jhon Pintos | 2 | 15 |
 | Danilo Cócaro | 2 | 19 |
 | Gonzalo Ramos | 2 | 13 |
| Agustín Miranda | 2 | 20 |
 | Emiliano Tracchia | 2 | 5 |
| Joaquín Valiente | 2 | 21 |
 | Diego Rosa | 2 | 8 |
| Leandro Sosa | 2 | 21 |
| Franco Mederos | 2 | 21 |
| Ricardo Lima | 2 | 19 |
| Joshuan Berrios | 2 | 15 |
| César Pereyra | 2 | 15 |
| Jimmy Evans | 2 | 17 |
 | Javier Méndez | 2 | 19 |
| Kevin Méndez | 2 | 14 |
| Emiliano Álvarez | 2 | 20 |
| Uri Amaral | 2 | 10 |
| Raúl Tarragona | 2 | 19 |
| Emanuel Hernández | 2 | 11 |
 | Sebastián Diana | 2 | 21 |
| Matías Roskopf | 2 | 16 |
 | Cristian Techera | 2 | 17 |
 | Leandro Rodríguez | 2 | 12 |
 | Jordan Mosquera | 2 | 18 |
| Juan Albín | 2 | 17 |
| Santiago Correa | 2 | 18 |
| Sergio Rodríguez | 2 | 19 |
| Maximiliano Juambeltz | 2 | 11 |
| Matías Alonso | 2 | 20 |
 | Jonathan Soto | 2 | 19 |
| Adrián Vila | 2 | 19 |
| Facundo Porley | 1 | 14 |
| Rafael Melo | 1 | 8 |
| Nicolás Rodríguez Petrini | 1 | 15 |
| Edwin Salazar | 1 | 9 |
 | Matías Alfonso | 1 | 20 |
 | Agustín Santurio | 1 | 7 |
| Darío Ferreira | 1 | 14 |
 | Lucas Ruíz Díaz | 1 | 12 |
| Federico Velázquez | 1 | 15 |
| Fabricio Santos | 1 | 15 |
| Guillermo Niski | 1 | 17 |
| Sebastián Cal | 1 | 16 |
| Matías Arismendi | 1 | 15 |
| Bruno Martín Correa | 1 | 15 |
| Joaquín Machado | 1 | 13 |
 | Martín Barrios | 1 | 17 |
| Franco O’ Neill | 1 | 8 |
| Darío Flores | 1 | 6 |
| Maximiliano Noble | 1 | 13 |
| Juan Millán | 1 | 2 |
 | Rafael Haller | 1 | 22 |
| Hernán De León | 1 | 18 |
| Christian Yeladian | 1 | 21 |
| Matías Ocampo | 1 | 20 |
| Agustín Chopitea | 1 | 16 |
| Federico Larraura | 1 | 10 |
| Gastón Alvite | 1 | 11 |
| Juan Pablo Fagúndez | 1 | 10 |
| Sebastián Cáceres | 1 | 9 |
| Damián Cabrera | 1 | 8 |
| Facundo Mallo | 1 | 21 |
| Gonzalo Bueno | 1 | 6 |
| Enzo Facchin | 1 | 14 |
| Maximiliano Bajter | 1 | 11 |
| Horacio Sequeira | 1 | 16 |
| Sebastián Gallegos | 1 | 19 |
| Gonzalo Gadea | 1 | 16 |
| Enzo Lemos | 1 | 13 |
| Leandro Reymundez | 1 | 2 |
 | Mauro Fernández | 1 | 2 |
| Fernando Elizari | 1 | 19 |
| Francisco Barrios | 1 | 19 |
| Delis Vargas | 1 | 14 |
| Anthony Sosa | 1 | 20 |
| Jorge Trinidad | 1 | 13 |
| Camilo Núñez | 1 | 19 |
 | Gian Allala | 1 | 13 |
| José Luis Rodríguez | 1 | 11 |
| Sebastián Gorga | 1 | 8 |
| Diego Vicente | 1 | 10 |
| José Luis Tancredi | 1 | 19 |
| Christian Alba | 1 | 8 |
| Líber Quiñones | 1 | 12 |
| Juan Manuel Olivera | 1 | 15 |
| Marcelo Tabárez | 1 | 10 |
| Matías Cabrera | 1 | 15 |
| Mathías Cardacio | 1 | 10 |
| Ignacio María González | 1 | 14 |
| Jorge Nicolás Ayala | 1 | 18 |
| Anyelo Rodríguez | 1 | 18 |
 | Juan Ignacio Moreira | 1 | 9 |
| Matías Rocha | 1 | 13 |
| Lucas Couto | 1 | 8 |
| Mauro Burruchaga | 1 | 10 |
| Maicol Ferreira | 1 | 8 |
| Fabián Píriz | 1 | 19 |
| Agustín Rodríguez | 1 | 14 |
| Juan Figueroa | 1 | 13 |
| Gonzalo Barreto | 1 | 20 |
| Gonzalo Viera | 1 | 22 |